Sunday 25th August
10.30am – 2.00pm
The role of extracellular vesicles in mediating ionizing radiation-induced bystander and systemic effects
Extracellular vesicles (EVs) are key mediators of intercellular communication both under physiological conditions and in a wide range of pathologies. Recent studies have shown the role of EVs in mediating radiation-induced bystander and systemic effects. One main aim of this satellite meeting is to present recent scientific data related to the impact of ionizing radiation on EV biology and function. In the frame of the Euratom-funded CONCERT project two research projects (LEU-TRACK and SEPARATE) specifically investigate the role of EVs in mediating radiation-induced bystander effects. LEU-TRACK focuses on the role of blood and bone marrow-derived EVs in mediating radiation-induced leukaemogenesis, and SEPARATE will investigate exosomes from exposed tissues, and their specific bioactive cargo, for their role in mediating out-of-target effects in vitro and in vivo A further specific aim of this satellite meeting is to present latest findings generated in these two projects.
Supporting organisation – This workshop is supported by the CONCERT project, which has received funding from the Euratom research and training programme 2014-2018 under grant agreement No 662287.
Website – http://www.concert-h2020.eu/
Monday 26th August
Monday pm – timings to be confirmed
Radiation effect on CNS during infancy: underlying mechanisms and implications on quality of life in adult and aging
Based on the outcome of the FP7 EU project CEREBRAD (Cognitive and cerebrovascular effects induced by low dose radiation) (GA n:295552) and based on the progress in the field of late radiation effect after childhood exposure (for diagnostic or therapy), this workshop will bring together epidemiologists, radiobiologists, dosimetrist, medical practionners to debate and make the state of the art on different aspects of the quality of life of adults previously exposed at young age in clinical settings. On the other hand more advanced molecular neuro findings to relate the cause to effect will be discussed to evaluate late cognitive impairments and accelerated aging.
Supporting organisation – SCK•CEN
Website – www.sckcen.be
Tuesday 27th August
Tuesday full day – timings to be confirmed
International Symposium on Chromosomal Aberrations ISCA12
All state-of-the-art technologies for basic and applied aspects of chromosomal aberrations, the elucidation of the mechanisms underlying their formation and their impact on chromosome fragility, genomic instability and carcinogenesis. The Symposium will give the opportunity to the invited speakers and participating scientists to present their work and share their vision on the latest achievements.
Tuesday 26th and Wednesday 27th August
Tuesday and Wednesday full days – timings to be confirmed
Radiobiology meets Radioecology : evidence for transgenerational and “memory” effects after low doses of ionising radiation
This workshop is the 5th in a series aiming to advance our understanding of the impacts of low doses of IR on populations and ecosystems. Past workshops have focused on multiple stressor issues, modelling, lessons from ecotoxicological fields and ecosystem level approaches in radiation protection resulting in a series of multi-authored publications. The theme this time is to seek contributors with knowledge of human and ecosystem level hereditary effects, memory effects, historic dose effects etc to discuss a series of provocative statements or questions relating to persistence of transgenerational effects in the environment
Supporting organisation – International Union of Radioecologists
Wednesday 28th August
3 hour workshop – timings to be confirmed
Clinical radiation sensitivity – who is affected?
The workshop focusses on clinical acute and late normal tissue reactions occurring after external beam radiation therapy. The workshop should contribute to clarifying the number of patients who would profit from a pre-screening test systems by discussing problems associated with:
- classifying patients in grades 2, 3 and 4 according to CTCAE criteria of different tumor entities,
- the correlation of acute and late radiation therapy treatment effects and the possible resulting actions in treatment change,
- the problems of subjective and non-quantitative classifying criteria,
- the value of imaging normal tissue complications for classification.
The outcome of the workshop is to give clear recommendations for harmonization and improvement of normal tissue complication classification and on who will be affected by potential treatment change.
Supporting organisation – Federal Office for Radiation Protection
Website – www.bfs.de