Sunday 25th August
The Role of Extracellular Vesicles in Mediating Ionizing Radiation-Induced Bystander and Systemic Effects
Extracellular vesicles (EVs) are key mediators of intercellular communication both under physiological conditions and in a wide range of pathologies. Recent studies have shown the role of EVs in mediating radiation-induced bystander and systemic effects. One main aim of this satellite meeting is to present recent scientific data related to the impact of ionizing radiation on EV biology and function.
In the frame of the Euratom-funded CONCERT project two research projects (LEU-TRACK and SEPARATE) specifically investigate the role of EVs in mediating radiation-induced bystander effects. LEU-TRACK focuses on the role of blood and bone marrow-derived EVs in mediating radiation-induced leukaemogenesis, and SEPARATE will investigate exosomes from exposed tissues, and their specific bioactive cargo, for their role in mediating out-of-target effects in vitro and in vivo A further specific aim of this satellite meeting is to present latest findings generated in these two projects.