Biological mechanisms responding to ionising radiation, including DNA repair and signalling, chromatin architecture/epigenetics, non-coding RNA, intercellular signalling (bystander responses) and radiation-induced signatures.Radiation chemistry and physics, including modelling. High LET/proton damage. Responses in neurones and stem cells. Radiation sensitive syndromes.
Pre-clinical research aimed at improving the use of radiation for therapy and diagnosis.
Includes: targeting DNA damage responses and hypoxia. Genomic determinants of radiosensitivity. Pre-clinical normal tissue radiobiology and consideration of distinct properties of cancer cells (e.g. metabolism and cancer stem cells). Pre-clinical studies of combined treatment modalities including immunotherapy. Nanotechnology and the use of microbeams.
Research interfacing at a clinical level.
Analysis and prediction of tumour and normal tissue responses to radiotherapy, including second cancer induction and benefit of fractionation. Molecular imaging, encompassing hypoxia. Clinical applications of particle therapy, radiation modifiers, precision radiotherapy and stem cell therapy. Modelling and theranostics. Interplay between radiotherapy and immunotherapy.
Health Effects and Ecology
Research of direct relevance to human health and our environment, encompassing low dose/ dose-rate exposures. Radiation induced carcinogenesis and non-cancer effects, and impacts on stem cells, transgenerational effects, inflammation and immune system. Space research and neuroscience. Ecology and environmental impacts. Psychological and societal effects, and mitigation.